Nana Konadu Agyeman, born on November 17, 1948, in Cape Coast, Ghana, attended Ghana International School, studied art and textiles at the University of Science and Technology, and later pursued various educational achievements, including a diploma in advanced personnel management and certificates from institutes in Ghana and the USA, including Johns Hopkins University and the Institute for Policy Studies.

Agyeman-Rawlings served as the First Lady during her husband's military and civilian leadership in the late 1970s and 1980s, and later, she held prominent roles in the 31st December Women's Movement and her party, the National Democratic Congress.

Former First Lady Nana Konadu Agyeman Rawlings aimed to empower women for socio-economic and political progress, led the 31 December Women's Movement, and played a pivotal role in Ghana's economic revolution, recognising women's significance in the country's development.

Ghana's first lady accompanied her husband on a nationwide U.S. tour to promote investment and trade. She also completed a fellows program in philanthropy and non-profit organisations at Johns Hopkins University, receiving a certificate, and both she and her husband were awarded honorary doctorate degrees from Lincoln University in 1995.

In 2016, she made history as the first woman to run for President of Ghana, earning the nickname "The Hillary Clinton of Africa." In the 2016 election, she ran with her newly formed party but received 0.16% of the votes. She also submitted her nomination forms to lead her party, the National Democratic Party (NDP), in the 2020 general elections.

Nana Konadu married Rawlings in 1977 and had four children together. When her husband passed away in November 2020, shortly before the election, she reduced her campaign activity but remained a candidate.

Nana Konadu Agyeman-Rawlings passed away on October 23, 2025, at the Ridge Hospital in Accra, Ghana, following a brief illness.