Vincent rose to fame in 2003 for his iconic portrayal of Max in the popular Ghanaian TV series Things We Do For Love, marking the start of his illustrious acting career.

In 2009, he played the role of Ben in My Sister’s Honour, demonstrating his evolving talent. In 2011, he successfully transitioned into movies, starring as Foo in Adams Apples. His portrayal of Donald in Caspers Energy (2015) earned him respect for his depth in character portrayal. In 2017, he captivated audiences with his charm as Jojo in My Very Ghanaian Wedding. The following year, he contributed to socially conscious storytelling with his role in Save the Street (2018). In 2020, he appeared in All or Nothing and portrayed Mark Anthony's dad in the TV series YOLO, a role he held from 2020 to 2022.

Apart from his work in film and television, Vincent served as an administrator at Soul Clinic International School, where he was deeply loved and respected by colleagues and students alike. 

Vincent McCauley underwent surgery for a brain tumor in South Africa but passed away shortly after on January 15, 2024. His death was officially announced on January 18, 2024, and the cause was linked to complications from the surgery.